Cannabis, Healthy Sleep, and Alzheimer’s Disease

 

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Cannabis, Healthy Sleep, and Alzheimer’s Disease

Histograms:

EEG (electroencephalograph) data showing unhealthy and healthy sleep.
(orange = difficulty sleeping)

CLICK TO ENLARGE

I.  Promoting Restorative (Slow Wave) and REM Sleep

1.  R. Tringale, MD and C. Jensen, MD, “Cannabis and Insomnia,” O’Shaughnessy’s, Autumn 2011, p 31-32, http://cannabisclinicians.org/wp-content/uploads/2011/09/Insomnia-Tringale.pdf)

2.  Sean Drummond, Ph.D, Abstract. Sleep and Medicinal Cannabis, CMCR (publication of study results pending completion of article for publication) http://www.cmcr.ucsd.edu/index.php?option=com_content&view=article&id=151:sleep-and-medicinal-cannabis&catid=41:research-studies&Itemid=135).

II.  Brain Cleaning, Sleep, and Neurodegenerative Disease

3.  Goodnight. Sleep clean. New York Times, http://www.nytimes.com/2014/01/12/opinion/sunday/goodnight-sleep-clean.html?_r=0 .

4.  Cannabinoids remove plaque-forming Alzheimer’s proteins from brain cells, Salk Institute, June 27, 2016 –  Preliminary lab studies at the Salk Institute find THC reduces beta amyloid proteins in human neurons, https://www.salk.edu/news-release/cannabinoids-remove-plaque-forming-alzheimers-proteins-from-brain-cells/ 

5.  Sleep Drives Metabolite Clearance from the Adult Brain, Science Magazine, http://www.sciencemag.org/content/342/6156/373 .

6.  Something to Sleep On, MD Magazine, http://www.hcplive.com/contributor/smita-patel-do/2015/07/something-to-sleep-on .

7.  Could Body Posture During Sleep Affect How Your Brain Clears Waste? Stony Brook University – Stony Brook Newsroom, http://sb.cc.stonybrook.edu/news/general/150804sleeping.php .

8.  Sleep (and specifically Slow-Wave Sleep), Older Adults, and Memory, Aging in America: Long Term Care & Aging In the 21st Century, https://olderadults.wordpress.com/2013/02/13/sleep-and-memory .

9.  Cohen’s Brain Bits: Brainsweeper, MedPage Today,  http://www.medpagetoday.com/Blogs/CohensBrainBits/53074?xid=nl_mpt_DHE_2015-08-15&eun=g592475d0r .

10. Structural and functional features of central nervous system lymphatic vessels, Nature, http://www.nature.com/nature/journal/v523/n7560/full/nature14432.html

11.  Seniors who don’t sleep well have higher levels of an Alzheimer’s biomarker, study says, Washington Post, Health and Science, 10/28/13 (http://www.washingtonpost.com/national/health-science/seniors-who-dont-sleep-well-have-higher-levels-of-an-alzheimers-biomarker-study-says/2013/10/28/5cf96d98-3c23-11e3-a94f-b58017bfee6c_story.html).

12. Self-reported Sleep and b-Amyloid Deposition in Community-Dwelling Older Adults, JAMA Neurology, December 2013, Vol. 70, No. 12; http://archneur.jamanetwork.com/article.aspx?articleid=1788611&resultClick=3).

13. The Potential Therapeutic Effects of THC on Alzheimer’s Disease, Journal of Alzheimer’s Disease, http://hscweb3.hsc.usf.edu/blog/2014/08/27/marijuana-compound-may-offer-treatment-alzheimers-disease-usf-preclinical-study-finds).

III. Hypothermia and Body Temperature

14. Estimation of the hypothermic component in neuroprotection provided by cannabinoids following cerebral ischemia, Neurochem Int., http://www.ncbi.nlm.nih.gov/pubmed/16730099).

15. A Cooling Effect from Cannabis, 420 Magazine, http://www.420magazine.com/forums/medical-marijuana-facts-information/79115-cooling-effect-cannabis.html) .

16. Effects of opioids, cannabinoids, and vanilloids on body temperature, Frontiers in Bioscience, https://www.bioscience.org/2011/v3s/af/190/fulltext.htm).

17. Cooling core body temperature may slow down neurodegeneration, CNS Spectr., http://www.ncbi.nlm.nih.gov/pubmed/18323756 ).

18. Hibernation protein could help repair dementia damage, National Health Service, NHS Choices, http://www.nhs.uk/news/2015/01january/pages/hibernation-protein-could-help-repair-dementia-damage.aspx).

IV. Neurogenesis, Cannabis, Sleep, and Inflammation

19. Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action, European Neuropsychopharmacology, http://www.ncbi.nlm.nih.gov/pubmed/19748235).

20. Sleep and adult neurogenesis: Implications for Cognition and Mood, Current Topics of Behavioral Neuroscience, http://www.ncbi.nlm.nih.gov/pubmed/24218292).

21. Cannabis and the Brain, a User’s Guide. NORML  http://norml.org/component/zoo/category/cannabis-and-the-brain-a-user-s-guide#Neurogenesis

22. Ways Cannabis Helps Fight Alzheimer’s. Leaf Science  http://www.leafscience.com/2014/03/20/5-ways-cannabis-help-fight-alzheimers/.